@inbook {1026, title = {Synthetic polysulfane derivatives induce cell cycle arrest and apoptotic cell death in human hematopoietic cancer cells}, booktitle = {Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 64}, year = {2013}, author = {Czepukojc, Brigitte and Baltes, Anne-Kathrin and Cerella, Claudia and Kelkel, Mareike and Maheswari Viswanathan, Uma and Salm, Franz and Burkholz, Thorsten and Schneider, Carolin C. and Dicato, Mario and Montenarh, Mathias and Jacob, Claus and Diederich, Marc F.} } @inbook {981, title = {ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis}, booktitle = {Carcinogenesis}, volume = {33}, year = {2012}, pages = {2162-2171}, edition = {11}, author = {Kelkel, Mareike and Cerella, Claudia and Mack, F. and Schneider, T. and Jacob, Claus and Schumacher, Marc and Dicato, Mario and Diederich, Marc F.} } @inbook {982, title = {Antioxidant and anti-proliferative properties of lycopene}, booktitle = {Free Radical Research}, volume = {45}, year = {2011}, pages = {925-940}, edition = {8}, doi = { 10.3109/10715762.2011.564168}, author = {Kelkel, Mareike and Schumacher, Marc and Dicato, Mario and Diederich, Marc F.} } @inbook {986, title = {Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer}, booktitle = {Biotechnology Advances}, volume = {29}, year = {2011}, pages = {531-547}, edition = {5}, abstract = {

Cancer is one of the most deadly diseases in the world. Although advances in the field of chemo-preventive and therapeutic medicine have been made regularly over the last ten years, the search for novel anticancer treatments continues. In this field, the marine environment, with its rich variety of organisms, is a largely untapped source of novel compounds with potent antitumor activity. Although many reviews of marine anticancer compounds have been published, we focus here on selected marine compounds that act on the six hallmarks of cancer presented namely self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replication, sustained angiogenesis and tissue invasion and metastasis.

}, author = {Schumacher, Marc and Kelkel, Mareike and Dicato, Mario and Diederich, Marc F.} } @inbook {988, title = {Naturally Occurring Organic Sulfur Compounds: An Example of a Multitasking Class of Phytochemicals in Anti-Cancer Research}, booktitle = {Phytochemcials}, year = {2011}, author = {Cerella, Claudia and Kelkel, Mareike and Viry, Elodie and Dicato, Mario and Jacob, Claus and Diederich, Marc F.} } @inbook {987, title = {A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010}, booktitle = {molecules}, volume = {16}, year = {2011}, pages = {5629-5646}, abstract = {

Although considerable progress in oncology therapeutics has been achieved in the last century, cancer remains one of major death causes in the World and for this reason, the development of novel cancer drugs remains a pressing need. Natural marine compounds represent an interesting source of novel leads with potent chemotherapeutic or chemo-preventive activities. In the last decades, structure-activity-relationship studies have led to the development of naturally-derived or semi-synthetic analogues with improved bioactivity, a simplified synthetic target or less toxicity. We aim here to review a selection of natural compounds with reported anticancer activity isolated of marine sources and their associated analogues published in 2010.

}, doi = {10.3390/molecules16075629}, author = {Schumacher, Marc and Kelkel, Mareike and Dicato, Mario and Diederich, Marc F.} } @inbook {989, title = {Potential of the Dietary Antioxidants Resveratrol and Curcumin in Prevention and Treatment of Hematologic Malignancie}, booktitle = {Molecules}, volume = {15}, year = {2010}, pages = {7035-7074}, edition = {10}, abstract = {

Despite considerable improvements in the tolerance and efficacy of novel chemotherapeutic agents, the mortality of hematological malignancies is still high due to therapy relapse, which is associated with bad prognosis. Dietary polyphenolic compounds are of growing interest as an alternative approach, especially in cancer treatment, as they have been proven to be safe and display strong antioxidant properties. Here, we provide evidence that both resveratrol and curcumin possess huge potential for application as both chemopreventive agents and anticancer drugs and might represent promising candidates for future treatment of leukemia. Both polyphenols are currently being tested in clinical trials. We describe the underlying mechanisms, but also focus on possible limitations and how they might be overcome in future clinical use--either by chemically synthesized derivatives or special formulations that improve bioavailability and pharmacokinetics.

}, doi = {10.3390/molecules15107035}, author = {Kelkel, Mareike and Jacob, Claus and Dicato, Mario and Diederich, Marc F.} }